TrueAllele solves 1963 Winnebago cold case using “inconclusive” DNA

    Background Readings

  1. Glossary: A glossary of terms


    Newspaper articles


    Magazine articles


    Newsletters


    Book chapters




    Validation Papers


    Laboratory data (5)



    Casework data (3)





    Validation Studies

  2. Validation Studies: A summary and list of citations of the TrueAllele validation studies.




    Forensic Applications


    World Trade Center DNA reanalysis – 18,500 victim remains and 2,700 missing people



    The United States National Institute of Standards and Technology (NIST) provides forensic laboratories with Standard Reference Material (SRM) mixture DNA that uses TrueAllele technology as a calibration standard to assess mixture weight and genotype composition



    Using TrueAllele as a laboratory instrument to measure DNA identification information





    DNA Exonerations

  3. A complete listing of TrueAllele exonerations is found here


    Regulatory Approvals




    Standards Compliance


    Standards



    Compliance





    Method Reports




    General Acceptance

  4. Bibliography: TrueAllele Casework is based on established methods.
  5. Citation Index: Other scientists refer to TrueAllele methods.


    TrueAllele usage in law and science


    TrueAllele method is well-suited for interpreting low-level DNA mixtures


    Relevant scientific community develops and assesses probabilistic DNA interpretation


    Forensic community accepts that probabilistic genotyping works better than thresholds




    Related Systems

    LSD (Tseiwei Wang, United States)
    Wang T, Xue N, Birdwell JD. Least-square deconvolution: a framework for interpreting short tandem repeat mixtures. J Forensic Sci. November 2006;51(6):1284-97.

    MCMC (James Curran, New Zealand)
    Curran JM. A MCMC method for resolving two person mixtures. Science & Justice. 2008;48(4): 168-177.

    MixSep (Torben Tvedebrink, Denmark)
    Tvedebrink T, Eriksen PS, Mogensen HS, Morling N. Identifying contributors of DNA mixtures by means of quantitative information of STR typing. J Comput Biol. 2012;19(7):887-902. http://cran.r-project.org/web/packages/mixsep/

    STRmix (John Buckleton, New Zealand)
    Taylor D, Bright J-A, Buckleton J. The interpretation of single source and mixed DNA profiles. Forensic Sci Int Genet. 2013;7(5):516–28. http://strmix.com

    DNA Insight (Roberto Puch-Solis, England)
    Puch-Solis R, Rodgers L, Mazumder A, Pope S, Evett I, Curran J, Balding D. Evaluating forensic DNA profiles using peak heights, allowing for multiple donors, allelic dropout and stutters. Forensic Sci Int Genet. 2013;7(5):555–63.

    DNAmixtures (Robert Cowell, England)
    Cowell RG, Graversen T, Lauritzen SL, Mortera J. Analysis of DNA mixtures with artefacts. Journal Royal Statistical Society, Series C Applied Statistics. 2015;64(1):1-48. http://dnamixtures.r-forge.r-project.org/

    DNA•VIEW Mixture Solution (Charles Brenner, United States)
    Brenner, C. The DNA•VIEW® Mixture Solution™. International Society for Forensic Genetics, Poster presentation. Krakow, Poland, September 2015. http://dna-view.com/#Mixtures

    LikeLTD (David Balding, Australia)
    Balding DJ, Steele CD. likeLTD v6.1: an illustrative analysis, explanation of the model, results of validation tests and version history. University College London, June 5, 2016. https://sites.google.com/site/baldingstatisticalgenetics/software/likeltd-r-forensic-dna-r-code

    EuroForMix (Peter Gill, Europe)
    Bleka Ø, Storvik G, Gill P. EuroForMix: An open source software based on a continuous model to evaluate STR DNA profiles from a mixture of contributors with artefacts. Forensic Sci Int Genet. March 2016;21:35-44.

    Kongoh (Keiji Tamake, Japan)
    Manabe S, Morimoto C, Hamano Y, Fujimoto S, Tamaki K. Development and validation of open-source software for DNA mixture interpretation based on a quantitative continuous model. PLoS ONE. 2017;12(11):e0188183.


    Admissibility Rulings

  6. A complete listing of TrueAllele admissibility rulings is found here



    Legal Commentary


    Some attorneys and scholars have commented on TrueAllele's objective approach, relative to subjective human review of DNA evidence.




    Scientific Development




    Other Papers


    Foundation


    Relevant