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Validating TrueAllele® genotyping on ten contributor DNA mixtures
D. Bauer and M.W. Perlin, "Validating TrueAllele® genotyping on ten contributor DNA mixtures", Mid-Atlantic Association of Forensic Scientists Annual Meeting, Pittsburgh, PA, 26-May-2017.
PowerPoint presentation of Dr. Bauer's talk.
With DNA mixtures, more contributors produce more complex data. Greater uncertainty makes data harder to interpret. We validated TrueAllele Casework on mixtures containing up to ten unknown contributors, measuring sensitivity, specificity, and reproducibility. We found that assumed contributor number had little impact on genotype inference. Moreover, DNA identification information depended more on the STR data than on program parameters.