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How TrueAllele® Works, Part 2: Degraded DNA and allele dropout

  • 20-Nov-2014, 1pm EDT

    TrueAllele Casework separates DNA mixtures into genotypes, solves kinship and paternity, and calculates match statistics. This half hour talk will focus on how TrueAllele handles degraded DNA and allele dropout.

    Speaker: Dr. Mark Perlin



PPTXPowerPoint presentation

PowerPoint handout


    Question and Answer Session



    Note

    Unlike TrueAllele, some STR mixture analysis methods discard peak data below a certain "threshold" height. The study by Kloosterman set a 10 rfu threshold (baseline noise) for TrueAllele, and a 50 rfu threshold for the other methods. Using a threshold, or adjusting its level, can significantly change the match statistic, as mentioned in the talk.