New publication - The reliability and reporting of DNA match strength for uncertain genotype evidence.

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1-Feb-2026

AAFS 2026 Conference


Cybergenetics will be presenting novel TrueAllele technology innovations in three talks at the upcoming 78th American Academy of Forensic Sciences annual conference in New Orleans, Louisiana in February 2026.

Cybergenetics will deliver three presentations showcasing new work with RapidHIT™ DNA identification, next-generation TrueAllele Investigative Databasing (TAID) solutions, and Next Generation Sequencing (NGS). Together, these advances expand what labs and law enforcement can do with in-house technology powered by TrueAllele.

Computer interpretation of RapidHIT™ mixtures for DNA match information

Speakers: Baron Andrus, MS, Mark Perlin, PhD, MD, PhD

  • The widespread RapidHIT™ DNA typing machines lets investigators generate a DNA profile from evidence in about 1.5 hours. Those fast results can be difficult to interpret with traditional methods, especially for complex samples.
  • Cybergenetics’ TrueAllele software enhances RapidHIT™ results by interpreting even the most challenging DNA evidence—such as mixtures or low-level samples—and turning them into clear, scientifically supported match statistics.
  • This presentation features a Louisiana State Police study showing how adding TrueAllele to RapidHIT™ workflows can quickly deliver useful, defensible answers—supporting both rapid investigative decisions and robust, courtroom-ready reporting.

Turning unsearchable mixtures into actionable intelligence for reliable DNA evidence

Speakers: Edward Schikel, MBA, Terrance Lewis MA, Mark Perlin, PhD, MD, PhD

  • Cybergenetics’ TrueAllele Investigative Database (TAID) helps agencies unlock the value of difficult DNA evidence—especially mixtures that older CODIS approaches often can’t search.
  • This presentation shows how TAID, combined with high-volume DNA testing, can quickly turn property-crime evidence into meaningful investigative leads and cross-case connections.
  • In a Montgomery County (PA) pilot study reviewing 1,234 evidence items, TAID generated many new links between items and produced new leads from many samples that had previously yielded no searchable result. The outcome: faster case progress, earlier intervention, and stronger, reportready results when it’s time to go to court.

Solving complex DNA mixtures with Next Generation Sequencing

Speakers: Kari Danser, MS, Mark Perlin, PhD, MD, PhD

  • Cybergenetics’ TrueAllele software can be paired with Next Generation Sequencing (NGS) to interpret especially challenging DNA evidence—such as complex mixtures with many contributors—where traditional approaches often fall short.
  • NGS can capture more information from difficult samples. Combined with TrueAllele’s powerful statistical analysis, labs can better separate contributors, identify unknowns, and support cold case work.
  • In this presentation, the speakers walk through a real Cleveland homicide case involving a seven-person mixture. They recreate the scenario using NGS validation data, demonstrating how the combined NGS–TrueAllele approach delivers clearer, stronger DNA associations.
  • The takeaway: using NGS and TrueAllele together expands what labs can reliably conclude from complex mixture evidence—and can ultimately strengthen case outcomes.


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