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Cybergenetics TrueAllele forensic DNA mixture interpretation validation study on known samples published in PLoS ONE journal

Pittsburgh, PA

Scientific methods used in court should be reliable, as established through validation studies. This study measured the identification information inferred from a set of forty DNA mixture and dilution samples of known composition. The validation compared Cybergenetics TrueAllele® probabilistic genotype computer interpretation with simpler human review approximations. The results demonstrated a log-log linear relationship between DNA quantity and match statistic. The computer methods were shown to be ten times more sensitive than human methods in detecting small DNA quantities and reporting accurate match statistics.

  • Perlin, M.W. and Sinelnikov, A. An information gap in DNA evidence interpretation. PLoS ONE, 2009;4(12):e8327. - Article
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