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20-Oct-1998

Cybergenetics Announces Automated Genotyping Evaluation Software

/PRNewswire/–Cybergenetics has developed an evaluation CD-ROM for its fully automated TrueAllele(TM) Technology genetic analysis software. TrueAllele eliminates the data scoring bottleneck for microsatellite genetic data.

"Conventional manual data editing is the single greatest source of cost, delay and error in high-throughput genotyping," says Dr. Mark Perlin, CEO of Cybergenetics. "Our TrueAllele Technology automates this data scoring, and can greatly accelerate the gene discovery process."

TrueAllele performs automated lane tracking and automated allele calling on gel image data from Perkin Elmer/Applied Biosystems and Pharmacia/ALF automated fluorescent DNA sequencers, and runs on the Macintosh, UNIX and PC computer platforms. Cybergenetics' free evaluation CD lets scientists use the current TrueAllele v1.02 automated scoring software for three months before they license the technology.

"Our Macintosh evaluation CD lets geneticists immediately use TrueAllele to speed up their gene discovery projects," says Dr. Perlin. "We have focused on simplicity and ease of use." To install, the user just copies the CD over to a hard drive. TrueAllele then starts up with a single click. Included is a PDF tutorial user manual, which the user can browse as hypertext, or read in printed hardcopy form.

The patented TrueAllele Technology is used at SmithKline Beecham (UK), deCODE genetics (Iceland), and various academic and government laboratories for high-throughput genotyping and gene discovery applications.

Cybergenetics is moving its TrueAllele software beyond the usual gene discovery applications into forensics, cancer genetics, differential display, and agricultural genetics. The new version 2.0 software includes novel methods for determining allele frequencies from pooled DNA samples, and improves performance by learning from past experience.

TrueAllele is built in MATLAB, a high-performance computer language by the MathWorks for numerical computation and data visualization. TrueAllele 2.0 now runs in MATLAB 5. The evaluation CD's ease of use was enabled by a special arrangement between Cybergenetics and the MathWorks.

Cybergenetics is a bioinformation company based in Pittsburgh, PA that develops unique computational approaches for genetic research. Cybergenetics is committed to providing effective software systems that accelerate and simplify genetic discovery.

For more information (or to request an evaluation CD) please contact Cybergenetics at info@cybergenetics-inc.com, or visit the http://www.cybergenetics-inc.com web site. Cybergenetics will be demonstrating its TrueAllele software at the annual genetics meeting later this month in Denver.

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