Cybergenetics TrueAllele Casework System provides automated background quality assurance processes for casework data (including mixtures). Quality assurance is currently a time consuming, labor intensive process that only partially characterizes the DNA process. Labs conduct special studies to determine the reproducibility of certain STR data variables. TrueAllele Casework's quality assurance features continuously monitor a wide range of STR variables on the actual forensic data. The wide range of TrueAllele Casework quality assurance computer processes operate automatically on lab data without human intervention, and provide ongoing reporting of its QA measurements.
Quality variables include size precision, peak variability, background noise, PCR stutter and relative amplification. Greater variation (i.e. less precision) suggests less reliable data. A forensic scientist can examine how these variables change over time in order to assess STR data reproducibility. The early detection of data variability can prevent problems and facilitate troubleshooting. This data is presented through a combination of unique spreadsheets and visual user interfaces for ease of use.
The TrueAllele Casework system can provide quality assurance assessments on casework STR processes across a variety of DNA sequencers and STR panels. TrueAllele Casework's quality assurance shows comparisons between DNA vendor labs that are helpful in quantifying quality, and in using high quality as an objective purchasing criterion (that complements low price). Quality comparisons within a laboratory illustrate how continuous quality assurance can lead to consistent results and quality improvements over time. Moreover, TrueAllele Casework quality assurance comparisons can help identify which instruments, panels, people and processes are more (or less) reliable. By shifting the burden of quality assurance from scientists to their computers, TrueAllele Casework's continuous quality assurance helps assure the integrity of the forensic DNA process.